Barely Significant
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Tumor-Associated Lactic Acidosis and Early Death in Patients With Lymphoma.

Cancer Med · 2025 · PMC11951173 · PMID 40152524

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Earlier administration of anti‐lymphoma therapy (chemotherapy or immunotherapy) trended with better survival outcomes but failed to reach statistical significance.

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a nonsignificant trendno p-value reported
Earlier initiation of anti‐lymphoma directed therapy (chemotherapy, immunotherapy, or both) was associated with a nonsignificant trend toward a better outcome; chemotherapy was initiated at an average of 5.5 days after documentation of the first elevated lactate in patients who survived at least 30 days (range (−)4–30), versus 9.05 days after the first elevated lactate in patients with ED (range 0–25, p = 0.13).

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