Prehospital tranexamic acid decreases early mortality in trauma patients: a systematic review and meta-analysis.

Front Med (Lausanne) · 2025 · PMC11951308 · PMID 40160319

Europe PMC DOI

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0.0900

closest p · 1.8× alpha

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boldest claim

The sentences

did not reach statistical significancep = 0.09so close (0.05 < p ≤ 0.1)

There was a 28.0% increase in VTE among PH TXA patients ( n = 416) compared to NO TXA patients ( n = 325), but this increase did not reach statistical significance (OR, 1.14; 95% CI, 0.98–1.33; p = 0.09). 3.3.3 Impact of prehospital TXA on 28–30-day mortality Nine studies reported mortality, including five reported 30-day mortality and four reported 28-day mortality ( Figure 5 ) ( 15 , 16 , 23 , 25 , 27 – 29 , 31 , 33 ).

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a decreasing trendno p-value reported

In this meta-analysis, the prehospital TXA was associated with a significant reduction in early mortality and a decreasing trend in overall mortality compared to patients who did not receive TXA, along with previous studies that also demonstrated a reduction in early mortality ( 22 , 46 ).

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an increasing trendno p-value reported

This meta-analysis revealed that prehospital TXA was associated with an increasing trend in the risk of VTE, even though it was not statistically significant.

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