Monocytic TLR4 expression and activation in schizophrenia: A systematic review and meta-analysis.

PLoS One · 2025 · PMC11952227 · PMID 40153412

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did not reach statistical significanceno p-value reported

However, these correlations did not reach statistical significance after eight weeks of AP treatment [ 28 ].

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a nonsignificant trendno p-value reported

Pooled analysis revealed a nonsignificant trend toward increased basal monocytic TLR4 density in PwSCZ (Hedges’ g = 0.317 [95% CI: –0.060, 0.694], τ2 = 0.127, I 2 = 68.91%).

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an overall trendno p-value reported

We observed an overall trend toward increased monocytic TLR4 density in persons with schizophrenia (regardless of AP status) compared to HCs, although the difference was not significant.

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