Muscle-specific Ryanodine receptor 1 properties underlie limb-girdle muscular dystrophy 2B/R2 progression.

Nat Commun · 2025 · PMC11953303 · PMID 40155594

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may be significantno p-value reported

Compounding oxidation of the RyR1 and subsequent accumulation of cytosolic Ca 2+ due to both increased RyR1 leakage and impaired PMCA activity may be significant factors that underlie the onset and progression of pathology.

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showed a trendno p-value reported

The mitochondrial Ca 2+ content in the BlaJ TA and psoas showed a trend towards an increase with age, but this was not significant.

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