Strategic delivery of omega-3 fatty acids for modulating inflammatory neurodegenerative diseases.

In the present study, n-3 treatment showed a trend of reducing pro-inflammatory cytokine expression in 7-day-old 5xFAD offspring, although statistical significance was not observed for some markers.

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Perinatal administration of n-3 TG resulted in a notable trend in decreased expression of major pro-inflammatory cytokines such as interleukin-1 alpha ( Il1α ) and Il1β (ns, Figures 1A , B ) in 5xFAD mice, n-3 treatment also reduced overall expression of Il12, Tnfa , or toll-like receptor 4 ( Tlr4 ), regardless of the genotype ( Figures 1D – F , ns).

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