mTOR inhibition modulates vaccine-induced immune responses to generate memory T cells in patients with solid tumors.

Notably, quantitative comparisons between Trial A and Trial B revealed that the addition of rapamycin reduced the magnitude of amplification in the humoral response throughout the monitoring period (median log 2 fold change: 7.45 in Trial A vs 3.69 in Trial B), although this difference did not reach statistical significance (p=0.121) ( figure 3B ).

also in 111,027 other papers