Modification of adipogenesis and oxidative stress by quercetin: positive or negative impact on adipose tissue metabolism of obese diabetic Zucker rats?

J Physiol Biochem · 2025 · PMC11958396 · PMID 39576482

Europe PMC DOI

hedged sentences

0.0580

closest p · 1.2× alpha

0.0990

boldest claim

The sentences

borderline significancep = 0.058so close (0.05 < p ≤ 0.1)

Moreover, we noted a borderline significance of the interaction of the two main factors ( p = 0.058), whereby in the group of lean animals, QCT tended to reduce the expression of AdipoR2, which did not occur in the group of obese ZDF rats (Fig. 7 D).

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at the limit of significancep = 0.08so close (0.05 < p ≤ 0.1)

We noted an increased expression of the mitochondrial biogenesis marker - peroxisome proliferator-activated receptor 1α coactivator ( Pgc1α ) by QCT administration at the limit of significance ( p = 0.08) only in ScWAT (Fig. 5 A).

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showed a trendp = 0.099so close (0.05 < p ≤ 0.1)

Administration of QCT showed a trend to decrease Irs2 expression ( p = 0.099), and a borderline significance of the interaction of the two main factors ( p = 0.058) was detected.

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