Detecting PI3K and TP53 Pathway Disruptions in Early-Onset Colorectal Cancer Among Hispanic/Latino Patients.

Cancer Med · 2025 · PMC11959147 · PMID 40165548

Europe PMC DOI

hedged sentences

0.2600

closest p · 5.2× alpha

0.2600

boldest claim

The sentences

did not reach statistical significancep = 0.26not close (p > 0.1)

PI3K alterations were present in 39.9% of early‐onset patients compared to 47% of late‐onset patients, although this difference did not reach statistical significance ( p = 0.26).

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an apparent trendno p-value reported

These findings suggest that while there is an apparent trend of poorer survival outcomes in patients with TP53 alterations, this difference may not be reliable and could be due to chance.

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