Transcriptomic atlas reveals organ-specific disease tolerance in sickle cell mice.

Although the bone marrow inflammatory signature did not reach statistical significance here, previous transcriptomic analysis of bone marrow–sorted mesenchymal stem cells from HbSS mice, compared with HbAS, found alterations in TLR4 and NF-κB activation, ROS accumulation, and decreased self-renewal. 34 Even though the consequences of microcirculation anomalies are at the forefront of clinical practice, intravascular hemolysis and heme release are also key triggers of the inflammatory process. 35 TLR4 signaling is induced by heme, 14 , 15 , 36 , 37 , 38 , 39 which may explain in part the inflammatory pattern we detect here.

also in 111,027 other papers