The inflammatory and genetic mechanisms underlying the cumulative effect of co-occurring pain conditions on depression.

The estimation based on other MR methods including weighted median (OR = 1.99, 95% CI = [1.62, 2.45], P = 6.52 × 10 −11 ) simple median (OR = 2.04, 95% CI = [1.66, 2.51], P = 1.68 × 10 −11 ), MR Egger (OR = 2.29, 95% CI = [1.10, 4.77], P = 8.00 × 10 −3 ), and IVW under fixed effect (OR = 2.07, 95% CI = [1.85, 2.31], P = 1.06 × 10 −37 ) revealed comparable effect sizes, but the MR Egger method was only marginally significant (Bonferroni-corrected significance threshold P < 0.05/9).

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