Association between methylenetetrahydrofolate reductase C677T polymorphism and cerebral small vessel disease: a systematic review and meta-analysis.

Front Neurol · 2025 · PMC11965132 · PMID 40183010

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nominally significantno p-value reported

Although our meta-analysis identified a nominally significant association between the MTHFR C677T polymorphism and CSVD, we recognize the need to interpret these findings within clinical practice.

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a positive trendno p-value reported

Our analysis suggests a positive trend but without statistical significance.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.