Discomfort towards peers causes therapy-related stress in children and adolescents on daily rhGH therapy.

Front Endocrinol (Lausanne) · 2025 · PMC11966424 · PMID 40182631

Europe PMC DOI

hedged sentences

0.0690

closest p · 1.4× alpha

0.0690

boldest claim

The sentences

borderline significantp=0.069so close (0.05 < p ≤ 0.1)

Multivariate regression analysis confirmed the significant influence of discomfort towards peers on chronic therapy-related stress independently of gender, age and pubertal stage (OR 4.84, 95%CI 1.30-17.99; p=0.019), whereas the influence of fear of needles was borderline significant (OR 3.18, 95% CI 0.913 - 11.07; p=0.069) ( Table 3 ).

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did not reach statistical significanceno p-value reported

Although this difference did not reach statistical significance, this finding suggests that the adolescent age, when peer interaction increases, may be at higher risk of developing therapy-related stress than the childhood age.

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