Cerebrospinal fluid Visinin-like protein-1 was associated with the relationship of body mass index with Alzheimer's disease pathology and cognition in non-demented elderly.

Associations between BMI and CSF AD core biomarkers and cognitive function In all participants, MLR models showed that continuous BMI variables were negatively correlated with the concentration of CSF P-tau (β = −0.29, p = 3.76 × 10 −5 ), T-tau (β = −2.51, p = 8.53 × 10 −5 ), P-tau/Aβ 42 (β = −6.51 × 10 −4 , p = 3.39 × 10 −6 ), and T-tau/Aβ 42 (β = −5.60 × 10 −3 , p = 2.71 × 10 −6 ), but the positive association with CSF Aβ 42 was at the threshold of significance (β = 6.31, p = 0.059) after controlling for aforementioned covariates ( Figure 2 and Supplemental Table 2A ).

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