Patients with post-COVID-19 condition show minor blood transcriptomic changes, with altered erythrocyte gene expression in a male subgroup.

145) between the HighE and NormE male groups, but this did not reach statistical significance.

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In the pathway analyses, the 11 PCC-specific DEGs showed highly significant enrichment to “Bone Marrow-erythrocyte” in the Tabula Sapiens database and to “Heme metabolism” in the MSigDB database ( Figure 4E ). 3.5 Subset of male patients with PCC demonstrate a high fraction of erythroblasts and have abnormal heme metabolism and biosynthesis in blood transcriptome To identify the possible cellular differences between PCC, Recov, and Ctrl male subjects, we used a deconvolution method to identify transcriptional cell subtype fractions.

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