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Enduring differential patterns of neuronal loss and myelination along 6-month pulsatile gonadotropin-releasing hormone therapy in individuals with Down syndrome.

Brain Commun · 2025 · PMC11969670 · PMID 40190351

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showed a trendno p-value reported
Interaction between cognitive and brain anatomy changes over time The post hoc regression analysis between MoCA improvement, regional GM volume and microstructure indices showed a trend for a negative correlation between MoCA improvement and R1 changes in cortical areas, contrasted with positive trends in bilateral prefrontal and parietal areas for MTsat and R2* ( P uncorr : *<0.05, **<0.01 and ***<0.001; Supplementary Fig. 3 ).

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