We identified a strong trend toward CH-Tum being associated with the aggressive, mesenchymal GBM subtype (OR = 6.55 [0.70–61.1], logistic regression; Figure 4 B). 42 The mesenchymal GBM subtype is known to be particularly rich with immune infiltration compared to the other subtypes, which we observed in this cohort (mesenchymal vs. classical p adj = 1 × 10 −9 ; vs.
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Inflammatory reprogramming of the solid tumor microenvironment by infiltrating clonal hematopoiesis is associated with adverse outcomes.
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