Direct-acting antivirals (DAA) positively affect depression and cognitive function in patients with chronic hepatitis C.

PLoS One · 2025 · PMC11970650 · PMID 40184345

Europe PMC DOI

hedged sentences

0.0600

closest p · 1.2× alpha

0.0600

boldest claim

The sentences

did not reach statistical significancep = 0.06so close (0.05 < p ≤ 0.1)

Interestingly, while there was no improvement in neuroticism among advanced liver disease patients, there was some positive change in those with milder forms of liver disease (6.5 ± 5.6 vs 5.0 ± 3.3) but this difference did not reach statistical significance (p = 0.06).

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highly significantno p-value reported

Most strikingly, there was a highly significant drop in depression scores after the end of therapy (BDI 8.8 ± 6.6 vs 6.1 ± 6.1; < 0.0001).

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