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Dynamic functional assessment of T cells reveals an early suppression correlating with adverse outcome in polytraumatized patients.

Front Immunol · 2025 · PMC11973370 · PMID 40196124

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The investigation of T-helper (Th) cell specific cytokine release in trauma patients revealed conflicting results: Patients presenting with hemorrhagic shock showed a trend toward higher cytokine concentrations for the Th2-specific cytokines IL-4 and IL-10 with lower concentrations for the Th1-specific cytokines Interferon γ (IFN-γ) and IL-2 ( 15 ).

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