Mitochondrial fusion and cristae reorganization facilitate acquisition of cardiomyocyte identity during reprogramming of murine fibroblasts.

Basal, ATP-linked, and ROS-linked OCRs remained largely stable for mnCMs between 2 and 7 days in culture, but the spare capacity at week 1 showed a highly significant increase over matched mnCF controls.

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The other components of FIS showed a trend toward lower mitochondrial numbers normalized by total length (fission) and no change to nodes normalized by total length (norm. nodes) ( Figures 1J and 1K ).

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