Gut microbiota contributes to protection against porcine deltacoronavirus infection in piglets by modulating intestinal barrier and microbiome.

At the genus level, compared to the control and PDCoV-infected piglets, Veillonella and Selenomonas levels were increased, while there was a decreasing trend for Lactobacillus , Streptococcus , and Mitsuokella in PDCoV-infected recipient piglets (Fig. 6 B).

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In exploring the connection between FMT-induced microbial changes and the modulation of the intestinal physiological function, we observed that FMT significantly increased the proportions of pathways involved in tryptophan metabolism and cytochrome P450, while decreasing proportions of pathways associated with NOD-like receptor, linoleic acid metabolism, and fructose and mannose metabolism showed a trend to increase.

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