Long-term effectiveness and safety of methotrexate-tacrolimus combination therapy versus methotrexate monotherapy in reducing rheumatoid arthritis flares after TNF inhibitor discontinuation: a retrospective cohort study.

Over a median follow-up of 8.6 years, with targeting tacrolimus blood trough concentrations at 3–5 ng/mL, tacrolimus users showed a marginally significant trend toward increased creatinine levels compared to non-users.

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The only exception was irreversible HAQ-DI worsening, which did not reach statistical significance in the univariable analysis (Fig. 2 , Supplementary Tables 1 and 2 ).

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