Single-cell sequencing and spatial transcriptomics reveal the evolution of glucose metabolism in hepatocellular carcinoma and identify G6PD as a potential therapeutic target.

For HCC5C and For HCC5C and HCC5D ( Figures 2D, E ), both glycolysis and TCA cycle activities exhibited an increasing trend, whereas PPP activity consistently decreased from the central core to the outer periphery.

also in 63,971 other papers

In HCC5B ( Figure 2C ), glycolysis and TCA cycle metabolic scores showed a trend of initially decreasing and then increasing towards the out periphery, while the PPP activity consistently decreased.

also in 53,322 other papers