After 12 weeks of HFD, hepatic Angptl3 gene transfer induced a 1.3-fold increase in mRNA expression of Angptl3 compared with that in the vector group, but the difference did not reach statistical significance (p = 0.11, n = 6–10).
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ANGPTL3 accelerates atherosclerotic progression via direct regulation of M1 macrophage activation in plaque.
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