Spatiotemporal proteomic and transcriptomic landscape of DAT+ dopaminergic neurons development and function.

The data indicated that within the same brain region, the total number of identified protein molecules shows a declining trend as development progresses ( Figure 2 A), whereas the transcriptome data do not exhibit a clear trend ( Figure 2 B).The Venn diagrams illustrated the results of proteomics and RNA-seq analyses across three specific brain regions (NAc, SNc, and VTA) and different developmental stages (P7, P30, and P60) ( Figures 2 C and 2D).

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