ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses.

Mol Neurodegener · 2025 · PMC11980231 · PMID 40200337

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hedged sentence

0.0590

closest p · 1.2× alpha

0.0590

boldest claim

The sentences

did not reach statistical significancep = 0.059so close (0.05 < p ≤ 0.1)

pMacs from with Grn -/- female mice exhibited similar phenotypic effects of Gpnmb knock-down, although this did not reach statistical significance (p = 0.059).

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