Effect of Brief Maternal Exposure to Bisphenol A on the Fetal Female Germline in a Mouse Model.

For BPA doses, however, one-way analysis of variance (ANOVA) indicated highly significant among-group differences ( F = 7.87 ; p < 0.0001 ), and subsequent Bonferroni post hoc comparisons indicated significant differences between placebo and each exposure ( t = 3.2 , p < 0.01 for 2 ng / g ; t = 2.8 , p < 0.01 for 20 ng / g ; t = 4.0 , p < 0.0001 for 100 ng / g ; and t = 5.4 , p < 0.0001 for 500 ng / g ).

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Subsequent evaluation of zygotene stage cells suggested the difference was apparent prior to SC formation ( Figure 5 ).

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