Inhibition of the metalloprotease ADAM19 as a novel senomorphic strategy to ameliorate gut permeability and senescence markers by modulating senescence-associated secretory phenotype (SASP).

Interestingly, our qRT-PCR in doxorubicin-treated mice showed a trend of increased cell cycle checkpoint maker p21 expression in the colon, which was significantly reduced by both doses (5 mg/kg and 10 mg/kg) of BB-94 ( Figure 2D ).

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