STAMBPL1 activates the GRHL3/HIF1A/VEGFA axis through interaction with FOXO1 to promote angiogenesis in triple-negative breast cancer.

Elife · 2025 · PMC11984952 · PMID 40208233

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quite significantno p-value reported

At the same time, it is not clear nor is being explained why different hypoxic conditions are sometimes used, resulting in different mRNA levels of HIF-1a and its downstream targets and quite significant fluctuations within the same cell line from one experimental setting to the next.

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