Barely Significant
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Aregs-IGFBP3-mediated SMC-like cells apoptosis impairs beige adipocytes formation in aged mice.

Mol Metab · 2025 · PMC11985090 · PMID 40118146

Europe PMCDOI
1
hedged sentence
0.0704
closest p · 1.4× alpha
0.0704
boldest claim

The sentences

did not reach statistical significancep = 7.04e-02so close (0.05 < p ≤ 0.1)
Although the p53 signaling pathway did not reach statistical significance (NES = 1.44, p = 7.04e-02), the upregulation of key genes such as Cdkn1a, Gadd45b, and Thbs1 suggests its collaborative role with TGFβ and MAPK signaling in inhibiting cell cycling or promoting apoptosis, contributing to the reduction of SMC-like cells.

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