A year in pharmacology: new drugs approved by the US Food and Drug Administration in 2024.

Naunyn Schmiedebergs Arch Pharmacol · 2025 · PMC11985671 · PMID 40163152

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a decreasing trendno p-value reported

The past 5 years show a decreasing trend in approvals of small molecules (from 70% in 2020 to about 50% in 2022–2024; Fig. 3 ).

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a clear trendno p-value reported

While the approval of antibodies (22–27%) and of peptides/proteins (2–19%) fails to show a clear trend, approvals of mRNA-based treatments, gene and cell therapy shows a major increase reaching about 20% of all approvals in the last 2 years (Fig. 3 ).

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