Synthesis, bioactivity, and molecular docking studies: novel arylpiperazine derivatives as potential new-resistant AR antagonists.

Further analysis revealed a clear trend among the tested arylpiperazine derivatives: a direct correlation between the binding affinity of compounds to AR and their antagonistic activity.

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Introduction According to the National Cancer Center of China’s 2024 National Cancer Report, there has been an increasing trend in both the incidence and mortality rates of prostate cancer in China in recent years, ranking sixth among the top ten malignant tumors in men ( Zheng et al., 2024 ).

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