Development of a Prognostic Score in Patients With Advanced Breast Cancer Treated for Meningeal Carcinomatosis.

Breast J · 2025 · PMC11991760 · PMID 40224951

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did not reach statistical significanceno p-value reported

Abnormal baseline Cyfra 21-1 did not reach statistical significance for prognosis, although evidence suggests that after the start of IT treatment, elevated CSF Cyfra 21-1 is an independent adverse prognostic factor [ 3 ].

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borderline significanceno p-value reported

The TN subtype ( p =0.0675) and a baseline CSF Cyfra 21-1 threshold value > 79 ng/mL (i.e., in the upper quartile; p =0.0544; C-index = 0.538) attained borderline significance and were therefore retained in the multivariate analyses.

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