Blood-based biomarkers for Alzheimer's disease in Down syndrome: A systematic review and meta-analysis.

However, when we combined multiple studies of plasma t‐tau in our meta‐analysis, we observed a highly significant effect ( z = 4.69, p < 0.00001).

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Finally, the potential overlap of participants in the studies included in our meta‐analysis may have contributed to the marginally significant findings of plasma Aβ42 between the DS with and without AD groups ( z = 2.03, p = 0.04). 4.2 Tau In this meta‐analysis, we examined two forms of tau and found no significant differences in plasma t‐tau (non‐phosphorylated tau) and p‐tau181 (phosphorylated tau) concentrations between the DS population and the euploid controls.

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70 It is important to note that one study, comparing plasma t‐tau levels between DS with AD and pAD, found a marginally significant difference that did not reach statistical significance. 39 This may be attributed to insufficient sample size in that particular study.

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