Association between dementia and left atrial appendage occlusion in patients with atrial fibrillation: A TriNetX-based retrospective cohort study with target trial emulation.

32 Despite this, there was a nonsignificant trend toward protective effects in individual dementia types, suggesting potential benefits that might become more evident with larger sample sizes or longer follow-up periods.

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▪ LAAO showed a trend toward reducing the risk of vascular dementia and Alzheimer disease, highlighting the need for further studies with larger cohorts or extended follow-up periods to better elucidate the effects of LAAO on specific types of dementia. ▪ The protective effect of LAAO in reducing dementia risk was consistent across various subgroups, including age, sex, types of atrial fibrillation, and specific types of DOACs used.

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