β-Adrenergic Blockers Increase cAMP and Stimulate Insulin Secretion Through a PKA/RYR2/TRPM5 Pathway in Pancreatic β-Cells In Vitro.

Propranolol substantially increased insulin secretion in diabetic A y / a islets (Figure 3E ), although it did not reach statistical significance in lean a / a islets (Figure 3D ).

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