Microglial ER stress response via IRE1α regulates diet-induced metabolic imbalance and obesity in mice.

Regardless, IRE1α and its target, sXBP1, were downregulated in the brain lysate of both male and female TMEM119 ERΔIRE1 mice, although the reduction in sXBP1 did not reach statistical significance in males ( Figure 5 A–D).

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