Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers.

JHEP Rep · 2025 · PMC11998117 · PMID 40242314

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did not reach statistical significanceno p-value reported

Among them, a combination of two secreted proteins (SERPINA1, attractin [ATRN]), two cytokines (IL6, epidermal growth factor [EGF]), and bilirubin displayed a reproducible performance (AUROCs 0.83 in both cohorts) numerically surpassing the AUROC of the ALFSG-PI score (AUROCs 0.75 in both cohorts), but the difference did not reach statistical significance.

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