Huang-Lian-Jie-Du decoction alleviates cognitive deficits in Alzheimer's disease model 5xFAD mice by inhibiting Trem2/Dap12 signaling pathway.

Chin Med · 2025 · PMC11998141 · PMID 40234956

Europe PMC DOI

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a decreasing trendP > 0.05actually significant

However, it did not significantly affect Csf1r, although a decreasing trend was observed ( P > 0.05) (Fig. 7 L–O).

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showed a trendno p-value reported

HLJD at low dose showed a trend to reduce the levels of Trem2, and it significantly suppressed the expression of Dap12 protein levels ( P < 0.05).

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