Mice with deletion of both Pten and Acly (hereafter, PTEN Δ/Δ ;ACLY Δ/Δ ) also showed increased levels of acetyl-CoA compared with PTEN mutants ( Figure 2 C-D), albeit this did not reach statistical significance when correction for multiple test hypothesis was applied.
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ATP citrate lyase is an essential player in the metabolic rewiring induced by PTEN loss during T-ALL development.
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