Physical activity of moderate-intensity optimizes myocardial citrate cycle in a murine model of heart failure.

Furthermore, as reflected by a significant interaction ( P = 0.004; Figure 2E ), the time spent on running by Tgα q *44 mice increased (∼29%) from the initial to the main stage of running, whereas in the WT mice, the time spent on running decreased (∼14%) from the initial to the main stage of 8-sWR; however, these differences did not reach statistical significance in post hoc analysis ( P > 0.05; Figure 2E ).

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