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Activation of VEGFR3 and MLC2 are Critical for GLP-2 Enhancement of Chylomicron Transport.

Gastro Hep Adv · 2025 · PMC12001124 · PMID 40242171

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showed a trendP = .08so close (0.05 < p ≤ 0.1)
As we showed in Figure 4 A and B, 15-minute GLP-2 treatment significantly induced the phosphorylation level of MLC2 by ∼2.2 fold ( P = .0096) in jejunum tissue samples, similar as VEGFR3 phosphorylation, the induction of MLC2 phosphorylation was blocked by the VEGFR3 inhibitor MAZ-51 ( P = .042), and the other inhibitor SAR131675 showed a trend of inhibition ( P = .08), indicating that both GLP-2 and VEGFR3 play roles in regulating smooth muscle contractions.

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