The HLA-DQ2.2 allele appears to confer protection, while the HLA-DQ2.5 allele has a weak association at the limits of significance and the strongly associated HLA-DRB1 04 haplotype is in LD with HLA-DQ7.3 and not with HLA-DQ8[ 73 , 74 ].
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Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease.
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