Single cell-resolved cellular, transcriptional, and epigenetic changes in mouse T cell populations linked to age-associated immune decline.

Proc Natl Acad Sci U S A · 2025 · PMC12002302 · PMID 40163732

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showed a trendno p-value reported

Our analysis revealed that the numbers of cytotoxic CD4+ T and dysfunctional CD4+ T cells increased with age, while CD4+ TEM population showed a trend toward increased numbers with age albeit with high variability, and an apparent drop in frequency at our latest age week 117 ( SI Appendix , Fig.

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a slight trendno p-value reported

S4 A ), individual analyses revealed a slight trend of decreased CD8+ T cells alongside an increase in CD4+ T cell populations with aging ( SI Appendix , Fig.

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