Control of circadian muscle glucose metabolism through the BMAL1-HIF axis in obesity.

Proc Natl Acad Sci U S A · 2025 · PMC12002348 · PMID 40127275

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0.0984

closest p · 2.0× alpha

0.0984

boldest claim

The sentences

a nonsignificant trendP = 0.0984so close (0.05 < p ≤ 0.1)

However, early glycolytic intermediates, such as glucose-6-phosphate (G6P), fructose-6-phosphate (F6P), and glucose-1-phosphate (G1P), which we grouped due to instrumental limitations, showed a nonsignificant trend toward reduced M + 6 labeling ( P = 0.0984) in Bmal1 mKO muscle ( Fig. 4 C ).

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showed a trendno p-value reported

While the control mice gained similar amounts of weight over the 20-wk HFD period, the Vhl mKO gained significantly less weight and d mKO mice showed a trend toward reduced weight gain over the course of the HFD feeding ( Fig. 6 B ).

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