(Apo)Lipoprotein Profiling with Multi-Omics Analysis Identified Medium-HDL-Targeting PSRC1 with Therapeutic Potential for Coronary Artery Disease.

FDR <0.05 was considered as significant and calculated by the Benjamini‐Hochberg method, and a p ‐value <0.05 was regarded as nominally significant.

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In multivariate MR (MVMR) analyses (Table S9 , Supporting Information), the associations of all six atherosclerosis‐associated HDL measurements with CAD risk persisted after adjustment for smoking and alcohol drinking, the two most heritable ASCVD risk factors [ 32 , 33 ] (ORs ranging from 0.77 to 0.87 [ p = 1.34E‐06 to 0.007; FDR = 8.05E‐06 to 0.007]), and adjustment for LDL‐c, the currently recommended primary target for lipid management [ 3 ] (ORs = 0.82 to 0.90 [ p = 6.21E‐05 to 0.027; FDR = 3.73E‐04 to 0.032]) except total lipids in medium HDL with marginal significance ( FDR = 0.055).

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