Activation of AMP-activated Protein Kinase by Metformin Inhibits Dedifferentiation of Platelet-derived Growth Factor-BB-induced Vascular Smooth Muscle Cells to Improve Arterial Remodeling in Cirrhotic Portal Hypertension.

Cell Mol Gastroenterol Hepatol · 2025 · PMC12008675 · PMID 40024535

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did not reach statistical significanceno p-value reported

Moreover, metformin treatment partially alleviated the cardiac load in BDL rats, leading to a decrease in both CO and CI, although this change did not reach statistical significance.

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