Effect of long-term treatment with memantine on mortality in patients with major cognitive disorders: A systematic review and meta-analysis.

Alzheimers Dement (N Y) · 2025 · PMC12009441 · PMID 40256206

Europe PMC DOI

hedged sentence

0.4500

closest p · 9.0× alpha

0.4500

boldest claim

The sentences

did not reach statistical significancep = 0.45not close (p > 0.1)

In the sensitivity analysis, the pooled RR was similar for randomized controlled trials (RCT) (RR 0.86) and non‐randomized studies (RR 0.81) but pooled results from RCTs did not reach statistical significance (95% confidence interval [CI]: 0.59–1.26, p = 0.45), while they did for observational studies (95% CI: 0.70–0.95, p = 0.008), so we consider the overall evidence as of low certainty.

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