The ratio of P-STAT3/P-STAT1 in monocyte-derived macrophages in the CCl4+IFNAR1 group was higher than in the CCl4-treated group with statistical significance and this difference in liver resident macrophages did not reach statistical significance ( Figure 5E ).
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Type I IFN receptor blockade alleviates liver fibrosis through macrophage-derived STAT3 signaling.
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