The mean MCP1 levels trended lower for SEFA-6179-pretreated mice compared to MCT-pretreated mice in the PN + saline (3954 ± 11742 vs 7665 ± 2191 pg/mL, P = 0.210), PN + Intralipid (3138 ± 300 vs 4016 ± 595 pg/mL, P = 0.236), and chow (2388 ± 342 vs 3417 ± 1056 pg/mL, P = 0.381) groups in the setting of LPS exposure, although this did not reach statistical significance.
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A medium-chain fatty acid analogue prevents endotoxin liver injury in a murine model.
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