Antitumor role of L-arginine and argininosuccinate synthetase 1 in hepatocellular carcinoma: direct and immunological mechanisms.

Although statistical significance was not observed, an analysis conducted on tissue samples from 58 patients with HCC revealed that in the group of patients with higher ASS1 expression in tumor tissues than adjacent peritumoral tissues, the 10-year overall survival rate after surgical resection showed a trend toward better prognosis. 2 Furthermore, in HCC cells cultured as three-dimensional spheroids, overexpression of ASS1 was shown to exert antitumor effects independently of p53 and arginine metabolism by activating the protein kinase RNA-like endoplasmic reticulum kinase /eukaryotic translation initi

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